منابع مشابه
Impact of the Gut Microbiota on Vaccine Responses
Non-responsiveness or poor responsiveness to vaccines are challenging issues in vaccine development, and efforts have been made to find out the potential reasons for these conditions. Intestinal microbiome plays a key role in regulating and development of immune system and the composition and diversity of microbiota in different individuals on the one hand, and the imbalance of intestinal micro...
متن کاملAn HIV-1 Mini Vaccine Induced Long-lived Cellular and Humoral Immune Responses
Memory formation is the most important aspect of a vaccine which can guarantee long-lasting immunity and protection. The main aim of the present study was to evaluate the memory immune responses after immunization with a mini vaccine. Mice were immunized with human immunodeficiency virus-1 P24-Nef fusion peptide and then cellular and humoral immune responses were evaluated. In order to determin...
متن کاملStool microbiota and vaccine responses of infants.
OBJECTIVE Oral vaccine efficacy is low in less-developed countries, perhaps due to intestinal dysbiosis. This study determined if stool microbiota composition predicted infant oral and parenteral vaccine responses. METHODS The stool microbiota of 48 Bangladeshi infants was characterized at 6, 11, and 15 weeks of age by amplification and sequencing of the 16S ribosomal RNA gene V4 region and b...
متن کاملUnderstanding Poor Vaccine Responses: Transcriptomics of Vaccine Failure
Immunosenescence is a functional and phenotypic exhaustion observed in adaptive and innate immune cell subsets, leading to an increased rate of infection, decreased vaccine responsiveness, and autoimmunity (Aw, Silva, & Palmer, 2007). Immunosenescence occurs with advancing chronological age and in individuals with a chronic viral infection. These changes ultimately result in increased mortality...
متن کاملComparative Evaluation of Mx and Alum as Bio and Conventional Adjuvants in Inducing Immune Responses by Influenza DNA Vaccine
Background & Objective: DNA vaccines as a new generation of vaccines require adjuvant to improve vaccine immunogenicity; adjuvants can also increase the DNA vaccine efficacy. In this study, the effects of the host’s interferon-inducible Mx protein as bio adjuvant and conventional alum adjuvant were evaluated. Materials & Methods: The BALB/c mice were immunized by different prime-boost strate...
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ژورنال
عنوان ژورنال: British Dental Journal
سال: 2021
ISSN: 0007-0610,1476-5373
DOI: 10.1038/s41415-021-3177-7